Drug interactions
Chlorpromazine + Triptorelin
Severity: Moderate
Chlorpromazine and Triptorelin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation therapy with triptorelin can prolong the QT interval, and chlorpromazine adds to this risk. The combination may increase the risk of torsades de pointes.
What this interaction means in plain words
Chlorpromazine and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpromazine belongs to Central Nervous System; Triptorelin belongs to Endocrine.
Why it happens
Additive QT prolongation, with androgen deprivation affecting cardiac repolarization.
What to do
Assess the ECG and electrolytes at baseline and periodically, and consider an alternative antipsychotic if other QT risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicated
- Chlorpromazine + Dronedarone Contraindicated
- Chlorpromazine + Droperidol Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Chlorpromazine + Metrizamide Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
Other interactions of Triptorelin
Frequently asked questions
Can I take Chlorpromazine with Triptorelin?
MediHelp rates the interaction as moderate. Chlorpromazine and Triptorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation therapy with triptorelin can prolong the QT interval, and chlorpromazine adds to this risk. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Chlorpromazine and Triptorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess the ECG and electrolytes at baseline and periodically, and consider an alternative antipsychotic if other QT risk factors are present.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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