Drug interactions
Chlorpropamide + Disopyramide
Severity: Moderate
Chlorpropamide and Disopyramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide can cause hypoglycemia on its own, sometimes severe, particularly in older patients, those with renal impairment or malnutrition. Added to a long-acting sulfonylurea such as chlorpropamide, the risk of prolonged hypoglycemia is increased.
What this interaction means in plain words
Chlorpropamide and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorpropamide belongs to Endocrine; Disopyramide belongs to Cardiovascular.
Why it happens
Additive hypoglycemic effect, with disopyramide stimulating insulin release and enhancing insulin-mediated glucose lowering.
What to do
Monitor blood glucose frequently and educate the patient on hypoglycemia symptoms. Reduce the chlorpropamide dose or choose another antiarrhythmic if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorpropamide
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Chlorpropamide with Disopyramide?
MediHelp rates the interaction as moderate. Chlorpropamide and Disopyramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide can cause hypoglycemia on its own, sometimes severe, particularly in older patients, those with renal impairment or malnutrition. Added to a long-acting sulfonylurea such as chlorpropamide, the risk of prolonged hypoglycemia is increased.
How serious is the interaction between Chlorpropamide and Disopyramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and educate the patient on hypoglycemia symptoms. Reduce the chlorpropamide dose or choose another antiarrhythmic if hypoglycemia occurs.
What other medicines interact with Chlorpropamide?
MediHelp also lists interactions of Chlorpropamide with, for example, Ethanol, Exenatide, Insulin degludec-insulin aspart. The full list is on the Chlorpropamide page.
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