Drug interactions
Chlorpropamide + Posaconazole
Severity: Minor
Chlorpropamide and Posaconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorpropamide may be affected by azoles that inhibit CYP2C9, but posaconazole has little effect on this enzyme, so a meaningful interaction is uncertain. Any effect would be increased glucose lowering.
What this interaction means in plain words
Chlorpropamide and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorpropamide belongs to Endocrine; Posaconazole belongs to Anti Fungals.
Why it happens
Possible modest inhibition of sulfonylurea metabolism; not well established for posaconazole.
What to do
Monitor blood glucose when starting or stopping posaconazole and adjust the chlorpropamide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorpropamide and Posaconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Chlorpropamide
Frequently asked questions
Can I take Chlorpropamide with Posaconazole?
MediHelp rates the interaction as minor. Chlorpropamide and Posaconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorpropamide may be affected by azoles that inhibit CYP2C9, but posaconazole has little effect on this enzyme, so a meaningful interaction is uncertain. Any effect would be increased glucose lowering.
How serious is the interaction between Chlorpropamide and Posaconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping posaconazole and adjust the chlorpropamide dose if hypoglycemia occurs.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
