Drug interactions
Chlorthalidone + Vildagliptin
Severity: Minor
Chlorthalidone and Vildagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone may modestly raise blood glucose and so offset part of the glucose-lowering benefit of vildagliptin. The effect is generally small and manageable.
What this interaction means in plain words
Chlorthalidone and Vildagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorthalidone belongs to Cardiovascular; Vildagliptin belongs to Endocrine.
Why it happens
Thiazide-related impairment of insulin secretion and sensitivity, often via hypokalemia, opposes the antidiabetic effect.
What to do
Monitor glucose control when chlorthalidone is started or its dose changed, and adjust diabetes therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorthalidone
Other interactions of Vildagliptin
- Ciprofloxacin + Vildagliptin Moderate
- Deflazacort + Vildagliptin Moderate
- Dexamethasone + Vildagliptin Moderate
- Gemifloxacin + Vildagliptin Moderate
- Glimepiride + Vildagliptin Moderate
- Hydrochlorothiazide-lisinopril + Vildagliptin Moderate
Frequently asked questions
Can I take Chlorthalidone with Vildagliptin?
MediHelp rates the interaction as minor. Chlorthalidone and Vildagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chlorthalidone may modestly raise blood glucose and so offset part of the glucose-lowering benefit of vildagliptin. The effect is generally small and manageable.
How serious is the interaction between Chlorthalidone and Vildagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control when chlorthalidone is started or its dose changed, and adjust diabetes therapy if needed.
What other medicines interact with Chlorthalidone?
MediHelp also lists interactions of Chlorthalidone with, for example, Amifostine, Atenolol-chlorthalidone, Candesartan-hydrochlorothiazide. The full list is on the Chlorthalidone page.
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