Drug interactions
Chlorzoxazone + Dantrolene
Severity: Moderate
Chlorzoxazone and Dantrolene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause drowsiness, dizziness and weakness, and each carries a risk of liver injury. Combined use may worsen sedation and muscle weakness and add to hepatotoxicity concerns.
What this interaction means in plain words
Chlorzoxazone and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Dantrolene belongs to Musculoskeletal.
Why it happens
Additive CNS depression and muscle relaxation, with overlapping hepatotoxic potential.
What to do
Monitor liver function tests and sedation, and avoid use of both if hepatic impairment develops. Counsel on driving and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Dantrolene
Frequently asked questions
Can I take Chlorzoxazone with Dantrolene?
MediHelp rates the interaction as moderate. Chlorzoxazone and Dantrolene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause drowsiness, dizziness and weakness, and each carries a risk of liver injury. Combined use may worsen sedation and muscle weakness and add to hepatotoxicity concerns.
How serious is the interaction between Chlorzoxazone and Dantrolene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and sedation, and avoid use of both if hepatic impairment develops. Counsel on driving and falls.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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