Drug interactions
Chlorzoxazone + Melatonin
Severity: Minor
Chlorzoxazone and Melatonin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Melatonin has mild sedative properties and may add to the drowsiness caused by chlorzoxazone. The clinical effect is generally small.
What this interaction means in plain words
Chlorzoxazone and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Chlorzoxazone belongs to Musculoskeletal; Melatonin belongs to Gastrointestinal Tract.
Why it happens
Additive mild CNS depressant effects.
What to do
No dose change is usually needed; advise taking melatonin at bedtime and avoiding driving if drowsy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chlorzoxazone
Other interactions of Melatonin
- Fluvoxamine + Melatonin Major
- Alfentanil + Melatonin Moderate
- Belladonna and opium + Melatonin Moderate
- Buprenorphine buccal + Melatonin Moderate
- Butabarbital + Melatonin Moderate
- Butalbital + Melatonin Moderate
Frequently asked questions
Can I take Chlorzoxazone with Melatonin?
MediHelp rates the interaction as minor. Chlorzoxazone and Melatonin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Melatonin has mild sedative properties and may add to the drowsiness caused by chlorzoxazone. The clinical effect is generally small.
How serious is the interaction between Chlorzoxazone and Melatonin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; advise taking melatonin at bedtime and avoiding driving if drowsy.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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