Drug interactions
Chlorzoxazone + Mirtazapine
Severity: Moderate
Chlorzoxazone and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mirtazapine is markedly sedating through antihistamine activity, and with chlorzoxazone it may cause excessive drowsiness and impaired coordination. This is most relevant at the start of therapy or after dose increases.
What this interaction means in plain words
Chlorzoxazone and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with mirtazapine H1 antagonism adding to muscle relaxant sedation.
What to do
Monitor for oversedation and counsel on driving and alcohol. Consider lowering the dose or separating dosing to bedtime for mirtazapine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Chlorzoxazone with Mirtazapine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mirtazapine is markedly sedating through antihistamine activity, and with chlorzoxazone it may cause excessive drowsiness and impaired coordination. This is most relevant at the start of therapy or after dose increases.
How serious is the interaction between Chlorzoxazone and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and counsel on driving and alcohol. Consider lowering the dose or separating dosing to bedtime for mirtazapine.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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