Drug interactions
Chlorzoxazone + Stiripentol
Severity: Moderate
Chlorzoxazone and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol commonly causes somnolence, and chlorzoxazone can add to drowsiness and impaired alertness. Stiripentol also inhibits several CYP enzymes, which could raise chlorzoxazone exposure, though CYP2E1 is the main pathway for chlorzoxazone.
What this interaction means in plain words
Chlorzoxazone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible pharmacokinetic effects from stiripentol enzyme inhibition.
What to do
Monitor for excessive sedation and reduce the chlorzoxazone dose if needed. Warn patients about driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chlorzoxazone
Other interactions of Stiripentol
Frequently asked questions
Can I take Chlorzoxazone with Stiripentol?
MediHelp rates the interaction as moderate. Chlorzoxazone and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol commonly causes somnolence, and chlorzoxazone can add to drowsiness and impaired alertness. Stiripentol also inhibits several CYP enzymes, which could raise chlorzoxazone exposure, though CYP2E1 is the main pathway for chlorzoxazone.
How serious is the interaction between Chlorzoxazone and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and reduce the chlorzoxazone dose if needed. Warn patients about driving and alcohol use.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
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