Drug interactions
Chlorzoxazone + Trazodone
Severity: Moderate
Chlorzoxazone and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone is sedating, and together with chlorzoxazone may cause additive drowsiness, dizziness and orthostatic hypotension. This can impair driving and increase fall risk.
What this interaction means in plain words
Chlorzoxazone and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depression, with trazodone antihistaminic and alpha-1 blocking effects.
What to do
Monitor for oversedation and orthostatic symptoms, and advise caution with driving. Reduce the dose of one agent if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorzoxazone and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorzoxazone
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Chlorzoxazone with Trazodone?
MediHelp rates the interaction as moderate. Chlorzoxazone and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trazodone is sedating, and together with chlorzoxazone may cause additive drowsiness, dizziness and orthostatic hypotension. This can impair driving and increase fall risk.
How serious is the interaction between Chlorzoxazone and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and orthostatic symptoms, and advise caution with driving. Reduce the dose of one agent if sedation is excessive.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
