Drug interactions
Chlorzoxazone + Trimipramine
Severity: Moderate
Chlorzoxazone and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorzoxazone is a centrally acting muscle relaxant and trimipramine is a sedating tricyclic antidepressant. Taken together they can cause greater drowsiness, dizziness and psychomotor impairment than either drug alone, which raises the risk of falls and accidents.
What this interaction means in plain words
Chlorzoxazone and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorzoxazone belongs to Musculoskeletal; Trimipramine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Start with the lowest effective doses and counsel patients to avoid driving or hazardous tasks until response is known. Reduce the dose of one agent if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Chlorzoxazone and Trimipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Chlorzoxazone
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Chlorzoxazone with Trimipramine?
MediHelp rates the interaction as moderate. Chlorzoxazone and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorzoxazone is a centrally acting muscle relaxant and trimipramine is a sedating tricyclic antidepressant. Taken together they can cause greater drowsiness, dizziness and psychomotor impairment than either drug alone, which raises the risk of falls and accidents.
How serious is the interaction between Chlorzoxazone and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and counsel patients to avoid driving or hazardous tasks until response is known. Reduce the dose of one agent if excessive sedation occurs.
What other medicines interact with Chlorzoxazone?
MediHelp also lists interactions of Chlorzoxazone with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlorzoxazone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
