Drug interactions
Cholecalciferol + Indapamide
Severity: Moderate
Cholecalciferol and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide, a thiazide-like diuretic, reduces urinary calcium loss and can add to vitamin D's calcium-raising effect. Hypercalcemia is possible, especially with high vitamin D doses.
What this interaction means in plain words
Cholecalciferol and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholecalciferol belongs to Musculoskeletal; Indapamide belongs to Cardiovascular.
Why it happens
Increased distal tubular calcium reabsorption adds to vitamin D-enhanced calcium absorption.
What to do
Check serum calcium periodically and reduce the vitamin D dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholecalciferol
- Cholecalciferol + Digoxin Major
- Aluminum hydroxide + Cholecalciferol Moderate
- Calcium acetate + Cholecalciferol Moderate
- Calcium Carbonate + Cholecalciferol Moderate
- Calcium chloride + Cholecalciferol Moderate
- Calcium citrate + Cholecalciferol Moderate
Other interactions of Indapamide
Frequently asked questions
Can I take Cholecalciferol with Indapamide?
MediHelp rates the interaction as moderate. Cholecalciferol and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indapamide, a thiazide-like diuretic, reduces urinary calcium loss and can add to vitamin D's calcium-raising effect. Hypercalcemia is possible, especially with high vitamin D doses.
How serious is the interaction between Cholecalciferol and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium periodically and reduce the vitamin D dose if levels rise.
What other medicines interact with Cholecalciferol?
MediHelp also lists interactions of Cholecalciferol with, for example, Digoxin, Aluminum hydroxide, Calcium acetate. The full list is on the Cholecalciferol page.
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