Drug interactions
Cholera vaccine + Mitomycin
Severity: Moderate
Cholera vaccine and Mitomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitomycin is a cytotoxic, myelosuppressive agent that can blunt the immune response to vaccines. The cholera vaccine may therefore give less protection in patients receiving chemotherapy.
What this interaction means in plain words
Cholera vaccine and Mitomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic immunosuppression reduces the antibody response to vaccination.
What to do
Where possible, give the vaccine at least 2 weeks before starting chemotherapy or after immune recovery. Consider revaccination if it was given during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Dengue vaccine + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
Frequently asked questions
Can I take Cholera vaccine with Mitomycin?
MediHelp rates the interaction as moderate. Cholera vaccine and Mitomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitomycin is a cytotoxic, myelosuppressive agent that can blunt the immune response to vaccines. The cholera vaccine may therefore give less protection in patients receiving chemotherapy.
How serious is the interaction between Cholera vaccine and Mitomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, give the vaccine at least 2 weeks before starting chemotherapy or after immune recovery. Consider revaccination if it was given during treatment.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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