Drug interactions
Mitomycin + Palifermin
Severity: Major
Mitomycin and Palifermin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth, and giving it close to cytotoxic chemotherapy can increase the severity and duration of oral mucositis. The timing relative to chemotherapy therefore matters.
What this interaction means in plain words
Mitomycin and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mitomycin belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Stimulation of proliferation of epithelial cells, making them more vulnerable to cytotoxic damage when chemotherapy is given nearby.
What to do
Do not give palifermin within 24 hours before, during, or within 24 hours after mitomycin. Follow labeled scheduling around chemotherapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mitomycin
Other interactions of Palifermin
Frequently asked questions
Can I take Mitomycin with Palifermin?
MediHelp rates the interaction as major. Mitomycin and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palifermin stimulates epithelial cell growth, and giving it close to cytotoxic chemotherapy can increase the severity and duration of oral mucositis. The timing relative to chemotherapy therefore matters.
How serious is the interaction between Mitomycin and Palifermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or within 24 hours after mitomycin. Follow labeled scheduling around chemotherapy.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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