Drug interactions
Bacitracin + Mitomycin
Severity: Major
Bacitracin and Mitomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitomycin can cause nephrotoxicity, including hemolytic uremic syndrome. Systemic bacitracin is itself markedly nephrotoxic, so combined use raises the risk of kidney injury.
What this interaction means in plain words
Bacitracin and Mitomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin belongs to Miscellaneous; Mitomycin belongs to Oncology.
Why it happens
Additive nephrotoxicity through different renal injury mechanisms.
What to do
Avoid systemic bacitracin in patients receiving mitomycin and choose a non-nephrotoxic antibiotic. If unavoidable, monitor serum creatinine and urine output closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mitomycin
Other interactions of Bacitracin
- Bacitracin + Cidofovir Contraindicated
- Adefovir + Bacitracin Major
- Aldesleukin + Bacitracin Major
- Amikacin + Bacitracin Major
- Bacitracin + Carboplatin Major
- Bacitracin + Cisplatin Major
Frequently asked questions
Can I take Bacitracin with Mitomycin?
MediHelp rates the interaction as major. Bacitracin and Mitomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitomycin can cause nephrotoxicity, including hemolytic uremic syndrome. Systemic bacitracin is itself markedly nephrotoxic, so combined use raises the risk of kidney injury.
How serious is the interaction between Bacitracin and Mitomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic bacitracin in patients receiving mitomycin and choose a non-nephrotoxic antibiotic. If unavoidable, monitor serum creatinine and urine output closely.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Deferiprone, Dengue vaccine, Etrasimod. The full list is on the Mitomycin page.
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