Drug interactions
Deferiprone + Mitomycin
Severity: Major
Deferiprone and Mitomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitomycin is a myelosuppressive cytotoxic that can cause delayed and cumulative bone marrow suppression. Combined with deferiprone, the risk of severe neutropenia and agranulocytosis is increased.
What this interaction means in plain words
Deferiprone and Mitomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferiprone belongs to Miscellaneous; Mitomycin belongs to Oncology.
Why it happens
Additive myelosuppression affecting neutrophil production.
What to do
Avoid combined use if alternatives exist; otherwise monitor absolute neutrophil count more frequently and withhold deferiprone if neutropenia develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Mitomycin
Frequently asked questions
Can I take Deferiprone with Mitomycin?
MediHelp rates the interaction as major. Deferiprone and Mitomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitomycin is a myelosuppressive cytotoxic that can cause delayed and cumulative bone marrow suppression. Combined with deferiprone, the risk of severe neutropenia and agranulocytosis is increased.
How serious is the interaction between Deferiprone and Mitomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use if alternatives exist; otherwise monitor absolute neutrophil count more frequently and withhold deferiprone if neutropenia develops.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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