Drug interactions
Dengue vaccine + Mitomycin
Severity: Major
Dengue vaccine and Mitomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dengue vaccine is a live attenuated vaccine, and mitomycin is a cytotoxic immunosuppressant. Immunosuppression may blunt the vaccine response and could permit uncontrolled replication of the vaccine virus, raising the risk of vaccine-related infection.
What this interaction means in plain words
Dengue vaccine and Mitomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Cytotoxic immunosuppression reduces immune response to a live attenuated vaccine and may permit vaccine virus replication.
What to do
Avoid live vaccines during chemotherapy with mitomycin and delay vaccination until immune recovery, according to local guidance. Consider alternatives or revaccination after therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mitomycin
- Bacitracin + Mitomycin Major
- Deferiprone + Mitomycin Major
- Etrasimod + Mitomycin Major
- Fingolimod + Mitomycin Major
- Mitomycin + Palifermin Major
- Mitomycin + Trastuzumab deruxtecan Major
Frequently asked questions
Can I take Dengue vaccine with Mitomycin?
MediHelp rates the interaction as major. Dengue vaccine and Mitomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine is a live attenuated vaccine, and mitomycin is a cytotoxic immunosuppressant. Immunosuppression may blunt the vaccine response and could permit uncontrolled replication of the vaccine virus, raising the risk of vaccine-related infection.
How serious is the interaction between Dengue vaccine and Mitomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during chemotherapy with mitomycin and delay vaccination until immune recovery, according to local guidance. Consider alternatives or revaccination after therapy.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Etrasimod. The full list is on the Mitomycin page.
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