Drug interactions
Etrasimod + Mitomycin
Severity: Major
Etrasimod and Mitomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etrasimod reduces circulating lymphocytes, and mitomycin is a myelosuppressive cytotoxic agent. Together they may increase the risk of serious infection.
What this interaction means in plain words
Etrasimod and Mitomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Mitomycin belongs to Oncology.
Why it happens
Additive immunosuppression from S1P receptor modulation and cytotoxic myelosuppression.
What to do
Avoid combining where possible; if chemotherapy is needed, consider pausing etrasimod and monitor blood counts and for signs of infection. The lymphocyte-lowering effect of etrasimod persists for weeks after discontinuation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mitomycin
Other interactions of Etrasimod
- Abatacept + Etrasimod Major
- Amiodarone + Etrasimod Major
- Anagrelide + Etrasimod Major
- Anakinra + Etrasimod Major
- Anti-thymocyte + Etrasimod Major
- Asenapine + Etrasimod Major
Frequently asked questions
Can I take Etrasimod with Mitomycin?
MediHelp rates the interaction as major. Etrasimod and Mitomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod reduces circulating lymphocytes, and mitomycin is a myelosuppressive cytotoxic agent. Together they may increase the risk of serious infection.
How serious is the interaction between Etrasimod and Mitomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if chemotherapy is needed, consider pausing etrasimod and monitor blood counts and for signs of infection. The lymphocyte-lowering effect of etrasimod persists for weeks after discontinuation.
What other medicines interact with Mitomycin?
MediHelp also lists interactions of Mitomycin with, for example, Bacitracin, Deferiprone, Dengue vaccine. The full list is on the Mitomycin page.
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