Drug interactions
Fingolimod + Mitomycin
Severity: Major
Fingolimod and Mitomycin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitomycin causes delayed and cumulative myelosuppression, and fingolimod lowers lymphocyte counts. Combined use may increase infection risk.
What this interaction means in plain words
Fingolimod and Mitomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Fingolimod belongs to Central Nervous System; Mitomycin belongs to Oncology.
Why it happens
Additive immunosuppression from cytotoxic marrow suppression and fingolimod lymphocyte sequestration.
What to do
Avoid combination where possible; if used, monitor complete blood counts and for infection. Consider suspending fingolimod during chemotherapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contraindicated
- Bcg vaccine live + Fingolimod Contraindicated
- Fingolimod + Pimozide Contraindicated
- Fingolimod + Ponesimod Contraindicated
- Fingolimod + Quinidine Contraindicated
- Fingolimod + Siponimod Contraindicated
Other interactions of Mitomycin
Frequently asked questions
Can I take Fingolimod with Mitomycin?
MediHelp rates the interaction as major. Fingolimod and Mitomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitomycin causes delayed and cumulative myelosuppression, and fingolimod lowers lymphocyte counts. Combined use may increase infection risk.
How serious is the interaction between Fingolimod and Mitomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible; if used, monitor complete blood counts and for infection. Consider suspending fingolimod during chemotherapy.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
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