Drug interactions
Cholestyramine + Metolazone
Severity: Moderate
Cholestyramine and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine binds oral metolazone in the gut and reduces its absorption, which can weaken the diuretic and antihypertensive effect.
What this interaction means in plain words
Cholestyramine and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Metolazone belongs to Cardiovascular.
Why it happens
Anion-exchange resin binding of metolazone in the gastrointestinal tract reduces its bioavailability.
What to do
Give metolazone at least 1 hour before or 4 to 6 hours after cholestyramine, and monitor blood pressure and fluid status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Metolazone?
MediHelp rates the interaction as moderate. Cholestyramine and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine binds oral metolazone in the gut and reduces its absorption, which can weaken the diuretic and antihypertensive effect.
How serious is the interaction between Cholestyramine and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give metolazone at least 1 hour before or 4 to 6 hours after cholestyramine, and monitor blood pressure and fluid status.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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