Drug interactions
Cholestyramine + Pravastatin
Severity: Moderate
Cholestyramine and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine binds pravastatin in the gut and reduces its absorption. This lowers pravastatin exposure when the two are taken together.
What this interaction means in plain words
Cholestyramine and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Pravastatin belongs to Cardiovascular.
Why it happens
Bile acid sequestrant binding of pravastatin in the gastrointestinal tract, reducing absorption.
What to do
Give pravastatin at least 1 hour before or 4 hours after cholestyramine. Monitor lipid response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Pravastatin?
MediHelp rates the interaction as moderate. Cholestyramine and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cholestyramine binds pravastatin in the gut and reduces its absorption. This lowers pravastatin exposure when the two are taken together.
How serious is the interaction between Cholestyramine and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give pravastatin at least 1 hour before or 4 hours after cholestyramine. Monitor lipid response.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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