Drug interactions
Cholestyramine + Raloxifene
Severity: Major
Cholestyramine and Raloxifene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cholestyramine binds raloxifene in the gut and interrupts its enterohepatic recycling, markedly lowering raloxifene levels. This can reduce raloxifene efficacy.
What this interaction means in plain words
Cholestyramine and Raloxifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cholestyramine belongs to Cardiovascular; Raloxifene belongs to Endocrine.
Why it happens
Bile acid sequestrant binds raloxifene and blocks absorption and enterohepatic recirculation.
What to do
Avoid concurrent use as raloxifene labeling advises. If unavoidable, consider an alternative to one drug.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Raloxifene
- Ospemifene + Raloxifene Major
- Apalutamide + Raloxifene Moderate
- Levothyroxine + Raloxifene Moderate
- Famciclovir + Raloxifene Minor
Other interactions of Cholestyramine
Frequently asked questions
Can I take Cholestyramine with Raloxifene?
MediHelp rates the interaction as major. Cholestyramine and Raloxifene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cholestyramine binds raloxifene in the gut and interrupts its enterohepatic recycling, markedly lowering raloxifene levels. This can reduce raloxifene efficacy.
How serious is the interaction between Cholestyramine and Raloxifene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use as raloxifene labeling advises. If unavoidable, consider an alternative to one drug.
What other medicines interact with Raloxifene?
MediHelp also lists interactions of Raloxifene with, for example, Ospemifene, Apalutamide, Levothyroxine. The full list is on the Raloxifene page.
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