Drug interactions
Apalutamide + Raloxifene
Severity: Moderate
Apalutamide and Raloxifene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide is an inducer of UGT enzymes and CYP3A4, and raloxifene is cleared mainly by glucuronidation. Raloxifene exposure may fall and its effect may be reduced.
What this interaction means in plain words
Apalutamide and Raloxifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Raloxifene belongs to Endocrine.
Why it happens
Apalutamide induces UGT-mediated glucuronidation, increasing raloxifene clearance.
What to do
Monitor for reduced raloxifene efficacy, and consider an alternative bone-protective agent if this is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Raloxifene
- Cholestyramine + Raloxifene Major
- Ospemifene + Raloxifene Major
- Levothyroxine + Raloxifene Moderate
- Famciclovir + Raloxifene Minor
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Raloxifene?
MediHelp rates the interaction as moderate. Apalutamide and Raloxifene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide is an inducer of UGT enzymes and CYP3A4, and raloxifene is cleared mainly by glucuronidation. Raloxifene exposure may fall and its effect may be reduced.
How serious is the interaction between Apalutamide and Raloxifene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced raloxifene efficacy, and consider an alternative bone-protective agent if this is a concern.
What other medicines interact with Raloxifene?
MediHelp also lists interactions of Raloxifene with, for example, Cholestyramine, Ospemifene, Levothyroxine. The full list is on the Raloxifene page.
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