Drug interactions
Famciclovir + Raloxifene
Severity: Minor
Famciclovir and Raloxifene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famciclovir is a prodrug that is converted to its active form, penciclovir, partly through aldehyde oxidase. Raloxifene inhibits this enzyme in vitro, so it could lower penciclovir formation and reduce antiviral effect. The clinical relevance in patients has not been shown.
What this interaction means in plain words
Famciclovir and Raloxifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Famciclovir belongs to Anti Virals; Raloxifene belongs to Endocrine.
Why it happens
Raloxifene inhibits aldehyde oxidase in vitro, which may reduce conversion of 6-deoxypenciclovir to penciclovir.
What to do
No routine change is needed. If an infection responds poorly to famciclovir in a patient taking raloxifene, consider this interaction and review the antiviral choice or dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Raloxifene
- Cholestyramine + Raloxifene Major
- Ospemifene + Raloxifene Major
- Apalutamide + Raloxifene Moderate
- Levothyroxine + Raloxifene Moderate
Other interactions of Famciclovir
Frequently asked questions
Can I take Famciclovir with Raloxifene?
MediHelp rates the interaction as minor. Famciclovir and Raloxifene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famciclovir is a prodrug that is converted to its active form, penciclovir, partly through aldehyde oxidase. Raloxifene inhibits this enzyme in vitro, so it could lower penciclovir formation and reduce antiviral effect. The clinical relevance in patients has not been shown.
How serious is the interaction between Famciclovir and Raloxifene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. If an infection responds poorly to famciclovir in a patient taking raloxifene, consider this interaction and review the antiviral choice or dose.
What other medicines interact with Raloxifene?
MediHelp also lists interactions of Raloxifene with, for example, Cholestyramine, Ospemifene, Apalutamide. The full list is on the Raloxifene page.
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