Drug interactions
Cholestyramine + Vitamin d
Severity: Moderate
Cholestyramine and Vitamin d: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic cholestyramine use impairs absorption of fat-soluble vitamins including vitamin D, which may contribute to deficiency and bone loss.
What this interaction means in plain words
Cholestyramine and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Vitamin d belongs to Gastrointestinal Tract.
Why it happens
Bile acid sequestration reduces micellar solubilization and absorption of fat-soluble vitamins.
What to do
Take vitamin D at least 4 hours before cholestyramine. Monitor 25-hydroxyvitamin D levels in long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cholestyramine
Other interactions of Vitamin d
Frequently asked questions
Can I take Cholestyramine with Vitamin d?
MediHelp rates the interaction as moderate. Cholestyramine and Vitamin d can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chronic cholestyramine use impairs absorption of fat-soluble vitamins including vitamin D, which may contribute to deficiency and bone loss.
How serious is the interaction between Cholestyramine and Vitamin d?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take vitamin D at least 4 hours before cholestyramine. Monitor 25-hydroxyvitamin D levels in long-term therapy.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
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