Drug interactions
Ciclesonide + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Ciclesonide and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a potent CYP3A4 inhibitor and can substantially raise exposure to inhaled corticosteroids metabolized by CYP3A4. Cushing syndrome and adrenal suppression have been reported with boosted regimens and other inhaled corticosteroids. Ciclesonide may be affected less than fluticasone but the risk remains.
What this interaction means in plain words
Ciclesonide and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cobicistat inhibits CYP3A4, reducing clearance of ciclesonide's active metabolite.
What to do
Monitor for Cushingoid features and adrenal suppression, and use the lowest effective ciclesonide dose. Consider beclomethasone as an alternative for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Frequently asked questions
Can I take Ciclesonide with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Ciclesonide and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a potent CYP3A4 inhibitor and can substantially raise exposure to inhaled corticosteroids metabolized by CYP3A4. Cushing syndrome and adrenal suppression have been reported with boosted regimens and other inhaled corticosteroids. Ciclesonide may be affected less than fluticasone but the risk remains.
How serious is the interaction between Ciclesonide and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid features and adrenal suppression, and use the lowest effective ciclesonide dose. Consider beclomethasone as an alternative for long-term therapy.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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