Drug interactions
Ciclesonide + Clarithromycin
Severity: Moderate
Ciclesonide and Clarithromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Clarithromycin strongly inhibits CYP3A4 and may increase exposure to the active metabolite of ciclesonide. This could raise the risk of systemic corticosteroid effects, though the effect is generally less than with fluticasone.
What this interaction means in plain words
Ciclesonide and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciclesonide belongs to Respiratory; Clarithromycin belongs to Anti Bacterial.
Why it happens
CYP3A4 inhibition by clarithromycin reduces metabolism of ciclesonide and its active metabolite.
What to do
Monitor for signs of corticosteroid excess if used long term; for short antibiotic courses no change is generally needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Cobicistat Moderate
- Ciclesonide + Darunavir Moderate
Other interactions of Clarithromycin
- Astemizole + Clarithromycin Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Cisapride + Clarithromycin Contraindicated
- Clarithromycin + Colchicine Contraindicated
- Clarithromycin + Conivaptan Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
Frequently asked questions
Can I take Ciclesonide with Clarithromycin?
MediHelp rates the interaction as moderate. Ciclesonide and Clarithromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Clarithromycin strongly inhibits CYP3A4 and may increase exposure to the active metabolite of ciclesonide. This could raise the risk of systemic corticosteroid effects, though the effect is generally less than with fluticasone.
How serious is the interaction between Ciclesonide and Clarithromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess if used long term; for short antibiotic courses no change is generally needed.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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