Drug interactions
Apalutamide + Ciclesonide
Severity: Moderate
Apalutamide and Ciclesonide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide strongly induces CYP3A4 and may lower exposure to ciclesonide's active metabolite. This could reduce asthma control.
What this interaction means in plain words
Apalutamide and Ciclesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Ciclesonide belongs to Respiratory.
Why it happens
CYP3A4 induction by apalutamide increases metabolism of ciclesonide and its active metabolite.
What to do
Monitor asthma control and lung function, and step up therapy or switch the inhaled corticosteroid if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
- Ciclesonide + Darunavir Moderate
Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Frequently asked questions
Can I take Apalutamide with Ciclesonide?
MediHelp rates the interaction as moderate. Apalutamide and Ciclesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide strongly induces CYP3A4 and may lower exposure to ciclesonide's active metabolite. This could reduce asthma control.
How serious is the interaction between Apalutamide and Ciclesonide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma control and lung function, and step up therapy or switch the inhaled corticosteroid if control worsens.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Atazanavir, Ceritinib. The full list is on the Ciclesonide page.
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