Drug interactions
Atazanavir + Ciclesonide
Severity: Moderate
Atazanavir and Ciclesonide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Atazanavir is a strong CYP3A4 inhibitor and can increase exposure to the active metabolite of ciclesonide. Systemic corticosteroid effects such as Cushing's syndrome and adrenal suppression may result with prolonged use.
What this interaction means in plain words
Atazanavir and Ciclesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atazanavir belongs to Anti Virals; Ciclesonide belongs to Respiratory.
Why it happens
CYP3A4 inhibition by atazanavir reduces clearance of ciclesonide and its active metabolite.
What to do
Monitor for Cushing's features and adrenal suppression with long-term use. Consider an alternative inhaled corticosteroid such as beclomethasone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
- Ciclesonide + Darunavir Moderate
Other interactions of Atazanavir
- Alfuzosin + Atazanavir Contraindicated
- Atazanavir + Avanafil Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Atazanavir + Eplerenone Contraindicated
- Atazanavir + Ergotamine Contraindicated
Frequently asked questions
Can I take Atazanavir with Ciclesonide?
MediHelp rates the interaction as moderate. Atazanavir and Ciclesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Atazanavir is a strong CYP3A4 inhibitor and can increase exposure to the active metabolite of ciclesonide. Systemic corticosteroid effects such as Cushing's syndrome and adrenal suppression may result with prolonged use.
How serious is the interaction between Atazanavir and Ciclesonide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushing's features and adrenal suppression with long-term use. Consider an alternative inhaled corticosteroid such as beclomethasone.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Ceritinib. The full list is on the Ciclesonide page.
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