Drug interactions
Ceritinib + Ciclesonide
Severity: Moderate
Ceritinib and Ciclesonide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceritinib inhibits CYP3A4 and may increase ciclesonide exposure. Systemic corticosteroid effects are possible with prolonged use.
What this interaction means in plain words
Ceritinib and Ciclesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceritinib belongs to Oncology; Ciclesonide belongs to Respiratory.
Why it happens
CYP3A4 inhibition by ceritinib reduces ciclesonide metabolism.
What to do
Monitor for signs of systemic corticosteroid excess during prolonged co-use and use the lowest effective ciclesonide dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
- Ciclesonide + Darunavir Moderate
Other interactions of Ceritinib
- Ceritinib + Cisapride Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Ceritinib + Pimozide Contraindicated
- Ceritinib + Thioridazine Contraindicated
- Ceritinib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Ceritinib with Ciclesonide?
MediHelp rates the interaction as moderate. Ceritinib and Ciclesonide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceritinib inhibits CYP3A4 and may increase ciclesonide exposure. Systemic corticosteroid effects are possible with prolonged use.
How serious is the interaction between Ceritinib and Ciclesonide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of systemic corticosteroid excess during prolonged co-use and use the lowest effective ciclesonide dose.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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