Drug interactions
Ciclesonide + Cobicistat
Severity: Moderate
Ciclesonide and Cobicistat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cobicistat is a potent CYP3A4 inhibitor used as a pharmacokinetic booster and can raise ciclesonide exposure. Cushing's syndrome and adrenal suppression are recognised with boosted regimens and other inhaled corticosteroids.
What this interaction means in plain words
Ciclesonide and Cobicistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ciclesonide belongs to Respiratory; Cobicistat belongs to Miscellaneous.
Why it happens
Potent CYP3A4 inhibition by cobicistat decreases ciclesonide clearance.
What to do
Monitor for hypercortisolism and adrenal suppression with long-term use. Consider switching to beclomethasone if prolonged therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ciclesonide and Cobicistat, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Darunavir Moderate
Other interactions of Cobicistat
- Alfuzosin + Cobicistat Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Cobicistat + Colchicine Contraindicated
- Cobicistat + Dronedarone Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Cobicistat + Eplerenone Contraindicated
Frequently asked questions
Can I take Ciclesonide with Cobicistat?
MediHelp rates the interaction as moderate. Ciclesonide and Cobicistat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cobicistat is a potent CYP3A4 inhibitor used as a pharmacokinetic booster and can raise ciclesonide exposure. Cushing's syndrome and adrenal suppression are recognised with boosted regimens and other inhaled corticosteroids.
How serious is the interaction between Ciclesonide and Cobicistat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hypercortisolism and adrenal suppression with long-term use. Consider switching to beclomethasone if prolonged therapy is needed.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
