Drug interactions
Ciclesonide + Fosamprenavir
Severity: Moderate
Ciclesonide and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir is converted to amprenavir, which inhibits CYP3A4, particularly when ritonavir-boosted. Ciclesonide exposure may rise, increasing the risk of Cushing's syndrome and adrenal suppression with prolonged use.
What this interaction means in plain words
Ciclesonide and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by amprenavir (and ritonavir) reduces ciclesonide clearance.
What to do
Monitor for hypercortisolism and adrenal suppression with chronic therapy. Consider switching to beclomethasone.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Frequently asked questions
Can I take Ciclesonide with Fosamprenavir?
MediHelp rates the interaction as moderate. Ciclesonide and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir is converted to amprenavir, which inhibits CYP3A4, particularly when ritonavir-boosted. Ciclesonide exposure may rise, increasing the risk of Cushing's syndrome and adrenal suppression with prolonged use.
How serious is the interaction between Ciclesonide and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hypercortisolism and adrenal suppression with chronic therapy. Consider switching to beclomethasone.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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