Drug interactions
Ciclesonide + Nefazodone
Severity: Moderate
Ciclesonide and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone is a potent CYP3A4 inhibitor and may increase ciclesonide exposure. Systemic corticosteroid effects are possible with prolonged use.
What this interaction means in plain words
Ciclesonide and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potent CYP3A4 inhibition by nefazodone decreases ciclesonide clearance.
What to do
Monitor for signs of corticosteroid excess during long-term co-use. Use the lowest effective ciclesonide dose or consider an alternative corticosteroid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Frequently asked questions
Can I take Ciclesonide with Nefazodone?
MediHelp rates the interaction as moderate. Ciclesonide and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone is a potent CYP3A4 inhibitor and may increase ciclesonide exposure. Systemic corticosteroid effects are possible with prolonged use.
How serious is the interaction between Ciclesonide and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of corticosteroid excess during long-term co-use. Use the lowest effective ciclesonide dose or consider an alternative corticosteroid.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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