Drug interactions
Ciclesonide + Saquinavir
Severity: Moderate
Ciclesonide and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, usually ritonavir-boosted, inhibits CYP3A4 and may increase exposure to ciclesonide's active metabolite. Systemic corticosteroid effects are possible with prolonged use.
What this interaction means in plain words
Ciclesonide and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Saquinavir inhibits CYP3A4-mediated metabolism of ciclesonide and its active metabolite.
What to do
Monitor for Cushingoid features and adrenal suppression, and consider beclomethasone for long-term therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ciclesonide
- Ciclesonide + Ritonavir Major
- Apalutamide + Ciclesonide Moderate
- Atazanavir + Ciclesonide Moderate
- Ceritinib + Ciclesonide Moderate
- Ciclesonide + Clarithromycin Moderate
- Ciclesonide + Cobicistat Moderate
Frequently asked questions
Can I take Ciclesonide with Saquinavir?
MediHelp rates the interaction as moderate. Ciclesonide and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir, usually ritonavir-boosted, inhibits CYP3A4 and may increase exposure to ciclesonide's active metabolite. Systemic corticosteroid effects are possible with prolonged use.
How serious is the interaction between Ciclesonide and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid features and adrenal suppression, and consider beclomethasone for long-term therapy.
What other medicines interact with Ciclesonide?
MediHelp also lists interactions of Ciclesonide with, for example, Ritonavir, Apalutamide, Atazanavir. The full list is on the Ciclesonide page.
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