Drug interactions
Cidofovir + Emtricitabine
Severity: Moderate
Cidofovir and Emtricitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cidofovir is nephrotoxic and both drugs are cleared by the kidneys, so combined use may increase emtricitabine exposure and renal risk. Cidofovir requires probenecid and hydration, which can also affect renal handling of emtricitabine.
What this interaction means in plain words
Cidofovir and Emtricitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cidofovir belongs to Anti Virals; Emtricitabine belongs to Anti Virals.
Why it happens
Nephrotoxicity and competition for renal tubular secretion reduce emtricitabine clearance.
What to do
Monitor serum creatinine and adjust emtricitabine dosing to renal function. Avoid the combination if renal function is significantly impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Other interactions of Emtricitabine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Emtricitabine Contraindicated
- Atidarsagene autotemcel + Emtricitabine Major
- Betibeglogene autotemcel + Emtricitabine Major
- Elivaldogene autotemcel + Emtricitabine Major
- Emtricitabine + Lamivudine Major
- Emtricitabine + Lovotibeglogene autotemcel Major
Frequently asked questions
Can I take Cidofovir with Emtricitabine?
MediHelp rates the interaction as moderate. Cidofovir and Emtricitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cidofovir is nephrotoxic and both drugs are cleared by the kidneys, so combined use may increase emtricitabine exposure and renal risk. Cidofovir requires probenecid and hydration, which can also affect renal handling of emtricitabine.
How serious is the interaction between Cidofovir and Emtricitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and adjust emtricitabine dosing to renal function. Avoid the combination if renal function is significantly impaired.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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