Drug interactions
Cidofovir + Zidovudine
Severity: Moderate
Cidofovir and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cidofovir is given with probenecid, which reduces zidovudine clearance and raises its levels, increasing risk of hematologic toxicity. Both drugs can also cause marrow or renal effects.
What this interaction means in plain words
Cidofovir and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cidofovir belongs to Anti Virals; Zidovudine belongs to Anti Virals.
Why it happens
Probenecid co-administered with cidofovir inhibits glucuronidation and renal tubular secretion of zidovudine.
What to do
Reduce the zidovudine dose by half on days cidofovir with probenecid is given, or temporarily withhold it. Monitor blood counts.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cidofovir
- Amikacin + Cidofovir Contraindicated
- Amphotericin b deoxycholate + Cidofovir Contraindicated
- Amphotericin b + Cidofovir Contraindicated
- Bacitracin + Cidofovir Contraindicated
- Capreomycin + Cidofovir Contraindicated
- Cephaloridine + Cidofovir Contraindicated
Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Frequently asked questions
Can I take Cidofovir with Zidovudine?
MediHelp rates the interaction as moderate. Cidofovir and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cidofovir is given with probenecid, which reduces zidovudine clearance and raises its levels, increasing risk of hematologic toxicity. Both drugs can also cause marrow or renal effects.
How serious is the interaction between Cidofovir and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the zidovudine dose by half on days cidofovir with probenecid is given, or temporarily withhold it. Monitor blood counts.
What other medicines interact with Cidofovir?
MediHelp also lists interactions of Cidofovir with, for example, Amikacin, Amphotericin b deoxycholate, Amphotericin b. The full list is on the Cidofovir page.
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