Drug interactions
Cilostazol + Crofelemer
Severity: Minor
Cilostazol and Crofelemer: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Crofelemer may inhibit CYP3A4 locally in the gut, but it is minimally absorbed, so a meaningful rise in cilostazol exposure is unlikely. Clinical significance is probably small.
What this interaction means in plain words
Cilostazol and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cilostazol belongs to Cardiovascular; Crofelemer belongs to Gastrointestinal Tract.
Why it happens
Theoretical intestinal CYP3A4 inhibition by crofelemer; systemic inhibition is not expected due to minimal absorption.
What to do
No routine adjustment is needed; watch for cilostazol adverse effects such as headache, palpitations or diarrhea if symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cilostazol
Other interactions of Crofelemer
- Crofelemer + Ergotamine Moderate
- Alfuzosin + Crofelemer Minor
- Amiodarone + Crofelemer Minor
- Apixaban + Crofelemer Minor
- Aprepitant + Crofelemer Minor
- Armodafinil + Crofelemer Minor
Frequently asked questions
Can I take Cilostazol with Crofelemer?
MediHelp rates the interaction as minor. Cilostazol and Crofelemer have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Crofelemer may inhibit CYP3A4 locally in the gut, but it is minimally absorbed, so a meaningful rise in cilostazol exposure is unlikely. Clinical significance is probably small.
How serious is the interaction between Cilostazol and Crofelemer?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; watch for cilostazol adverse effects such as headache, palpitations or diarrhea if symptoms emerge.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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