Drug interactions
Cilostazol + Esomeprazole
Severity: Moderate
Cilostazol and Esomeprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esomeprazole inhibits CYP2C19 and may raise exposure to cilostazol's active metabolite, increasing the risk of headache, palpitations and tachycardia.
What this interaction means in plain words
Cilostazol and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Esomeprazole belongs to Gastrointestinal Tract.
Why it happens
Esomeprazole inhibits CYP2C19, reducing cilostazol metabolite clearance.
What to do
Reduce cilostazol to 50 mg twice daily with esomeprazole and monitor for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cilostazol and Esomeprazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Esomeprazole
- Esomeprazole + Mavacamten Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Esomeprazole Major
- Atazanavir + Esomeprazole Major
- Citalopram + Esomeprazole Major
- Clopidogrel + Esomeprazole Major
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Esomeprazole?
MediHelp rates the interaction as moderate. Cilostazol and Esomeprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esomeprazole inhibits CYP2C19 and may raise exposure to cilostazol's active metabolite, increasing the risk of headache, palpitations and tachycardia.
How serious is the interaction between Cilostazol and Esomeprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce cilostazol to 50 mg twice daily with esomeprazole and monitor for adverse effects.
What other medicines interact with Esomeprazole?
MediHelp also lists interactions of Esomeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Esomeprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
