Drug interactions
Cilostazol + Fedratinib
Severity: Moderate
Cilostazol and Fedratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fedratinib is a moderate CYP3A4 inhibitor and can increase exposure to CYP3A4 substrates such as cilostazol. This may increase headache, tachycardia and other dose-related effects.
What this interaction means in plain words
Cilostazol and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Fedratinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4 (and CYP2C19) by fedratinib reduces cilostazol metabolism.
What to do
Consider reducing cilostazol to 50 mg twice daily and monitor heart rate and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cilostazol
Other interactions of Fedratinib
- Fedratinib + Thioridazine Contraindicated
- Amobarbital + Fedratinib Major
- Apalutamide + Fedratinib Major
- Brexpiprazole + Fedratinib Major
- Carbamazepine + Fedratinib Major
- Chloramphenicol + Fedratinib Major
Frequently asked questions
Can I take Cilostazol with Fedratinib?
MediHelp rates the interaction as moderate. Cilostazol and Fedratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fedratinib is a moderate CYP3A4 inhibitor and can increase exposure to CYP3A4 substrates such as cilostazol. This may increase headache, tachycardia and other dose-related effects.
How serious is the interaction between Cilostazol and Fedratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing cilostazol to 50 mg twice daily and monitor heart rate and tolerability.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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