Drug interactions
Cilostazol + Fluconazole
Severity: Moderate
Cilostazol and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole inhibits CYP2C19 and CYP3A4 and can raise exposure to cilostazol and its active metabolite. This may increase headache, tachycardia, palpitations and other dose-related adverse effects.
What this interaction means in plain words
Cilostazol and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP2C19 and CYP3A4 metabolism of cilostazol, increasing exposure to cilostazol and its active metabolite.
What to do
Reduce the cilostazol dose to 50 mg twice daily during co-administration. Monitor for tachycardia, headache and fluid retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Fluconazole?
MediHelp rates the interaction as moderate. Cilostazol and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluconazole inhibits CYP2C19 and CYP3A4 and can raise exposure to cilostazol and its active metabolite. This may increase headache, tachycardia, palpitations and other dose-related adverse effects.
How serious is the interaction between Cilostazol and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the cilostazol dose to 50 mg twice daily during co-administration. Monitor for tachycardia, headache and fluid retention.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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