Drug interactions
Cilostazol + Loratadine
Severity: Minor
Cilostazol and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cilostazol is metabolized by CYP3A4 and CYP2C19 to active metabolites. Loratadine is not an established clinically meaningful inhibitor of these enzymes, so a relevant rise in cilostazol exposure is unlikely and the claim is largely theoretical.
What this interaction means in plain words
Cilostazol and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cilostazol belongs to Cardiovascular; Loratadine belongs to Respiratory.
Why it happens
Theoretical weak CYP2C19 inhibition by loratadine; no clinically established effect.
What to do
No dose change is generally needed. Monitor for cilostazol adverse effects such as headache, palpitations and diarrhea if symptoms arise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Other interactions of Cilostazol
Frequently asked questions
Can I take Cilostazol with Loratadine?
MediHelp rates the interaction as minor. Cilostazol and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cilostazol is metabolized by CYP3A4 and CYP2C19 to active metabolites. Loratadine is not an established clinically meaningful inhibitor of these enzymes, so a relevant rise in cilostazol exposure is unlikely and the claim is largely theoretical.
How serious is the interaction between Cilostazol and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed. Monitor for cilostazol adverse effects such as headache, palpitations and diarrhea if symptoms arise.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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