Drug interactions
Cilostazol + Rucaparib
Severity: Minor
Cilostazol and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP3A4 weakly and may modestly raise cilostazol concentrations. Increased cilostazol adverse effects are possible but not well documented.
What this interaction means in plain words
Cilostazol and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cilostazol belongs to Cardiovascular; Rucaparib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4 by rucaparib reduces cilostazol clearance.
What to do
Monitor for headache, palpitations and tachycardia. Reduce the cilostazol dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cilostazol
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Cilostazol with Rucaparib?
MediHelp rates the interaction as minor. Cilostazol and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP3A4 weakly and may modestly raise cilostazol concentrations. Increased cilostazol adverse effects are possible but not well documented.
How serious is the interaction between Cilostazol and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for headache, palpitations and tachycardia. Reduce the cilostazol dose if adverse effects emerge.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
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