Drug interactions
Cilostazol + Stiripentol
Severity: Moderate
Cilostazol and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol both inhibits and induces CYP3A4, so the net effect on cilostazol exposure is unpredictable. Cilostazol levels could rise or fall, changing efficacy or tolerability.
What this interaction means in plain words
Cilostazol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cilostazol belongs to Cardiovascular; Stiripentol belongs to Central Nervous System.
Why it happens
Mixed CYP3A4 inhibition and induction by stiripentol alters cilostazol metabolism.
What to do
Monitor for cilostazol adverse effects such as tachycardia and headache, and for loss of effect. Adjust the dose based on response and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cilostazol and Stiripentol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cilostazol
Other interactions of Stiripentol
Frequently asked questions
Can I take Cilostazol with Stiripentol?
MediHelp rates the interaction as moderate. Cilostazol and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol both inhibits and induces CYP3A4, so the net effect on cilostazol exposure is unpredictable. Cilostazol levels could rise or fall, changing efficacy or tolerability.
How serious is the interaction between Cilostazol and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cilostazol adverse effects such as tachycardia and headache, and for loss of effect. Adjust the dose based on response and tolerability.
What other medicines interact with Cilostazol?
MediHelp also lists interactions of Cilostazol with, for example, Abrocitinib, Anagrelide, Betrixaban. The full list is on the Cilostazol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
