Drug interactions
Cimetidine + Eletriptan
Severity: Moderate
Cimetidine and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine increases eletriptan exposure by inhibiting its CYP3A4 metabolism, with a modest rise in peak and total concentrations. Strong CYP3A4 inhibitors are contraindicated with eletriptan, but cimetidine's effect is much weaker.
What this interaction means in plain words
Cimetidine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Eletriptan belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated eletriptan metabolism by cimetidine.
What to do
Avoid a second eletriptan dose within 24 hours and observe for hypertension and triptan adverse effects; consider famotidine instead.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Cimetidine with Eletriptan?
MediHelp rates the interaction as moderate. Cimetidine and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine increases eletriptan exposure by inhibiting its CYP3A4 metabolism, with a modest rise in peak and total concentrations. Strong CYP3A4 inhibitors are contraindicated with eletriptan, but cimetidine's effect is much weaker.
How serious is the interaction between Cimetidine and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second eletriptan dose within 24 hours and observe for hypertension and triptan adverse effects; consider famotidine instead.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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