Drug interactions
Cimetidine + Estradiol
Severity: Minor
Cimetidine and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine may slightly decrease estradiol metabolism and increase its exposure. The clinical consequence is generally minor, with possible increases in estrogenic adverse effects.
What this interaction means in plain words
Cimetidine and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Estradiol belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4 and other hepatic enzymes by cimetidine reduces estradiol clearance.
What to do
No dose change is usually required; monitor for breast tenderness, bleeding changes, or other estrogenic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Frequently asked questions
Can I take Cimetidine with Estradiol?
MediHelp rates the interaction as minor. Cimetidine and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine may slightly decrease estradiol metabolism and increase its exposure. The clinical consequence is generally minor, with possible increases in estrogenic adverse effects.
How serious is the interaction between Cimetidine and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually required; monitor for breast tenderness, bleeding changes, or other estrogenic effects.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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