Drug interactions
Cimetidine + Finerenone
Severity: Moderate
Cimetidine and Finerenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a weak CYP3A4 inhibitor and can increase finerenone exposure, which is metabolized mainly by CYP3A4. Higher exposure raises the risk of hyperkalemia and related renal effects.
What this interaction means in plain words
Cimetidine and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cimetidine belongs to Gastrointestinal Tract; Finerenone belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 reduces first-pass and systemic clearance of finerenone.
What to do
Monitor serum potassium and renal function after starting or changing cimetidine and adjust finerenone dosing based on potassium results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Finerenone
- Carbamazepine + Finerenone Contraindicated
- Clarithromycin + Finerenone Contraindicated
- Ensitrelvir + Finerenone Contraindicated
- Finerenone + Itraconazole Contraindicated
- Finerenone + Ketoconazole Contraindicated
- Finerenone + Posaconazole Contraindicated
Frequently asked questions
Can I take Cimetidine with Finerenone?
MediHelp rates the interaction as moderate. Cimetidine and Finerenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cimetidine is a weak CYP3A4 inhibitor and can increase finerenone exposure, which is metabolized mainly by CYP3A4. Higher exposure raises the risk of hyperkalemia and related renal effects.
How serious is the interaction between Cimetidine and Finerenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function after starting or changing cimetidine and adjust finerenone dosing based on potassium results.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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