Drug interactions
Cimetidine + Mebendazole
Severity: Minor
Cimetidine and Mebendazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine can increase mebendazole plasma concentrations, which are normally low because of extensive first-pass metabolism. This is mostly relevant with prolonged high-dose therapy for systemic helminth infections such as hydatid disease.
What this interaction means in plain words
Cimetidine and Mebendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Mebendazole belongs to Anti Parasitic.
Why it happens
Cimetidine inhibits hepatic CYP-mediated metabolism of mebendazole.
What to do
No action is generally needed for short courses. During long-term high-dose mebendazole, monitor for adverse effects such as hepatotoxicity and neutropenia.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Mebendazole
- Deferiprone + Mebendazole Major
- Mebendazole + Metronidazole Major
- Acalabrutinib + Mebendazole Moderate
- Carbamazepine + Mebendazole Moderate
- Ethotoin + Mebendazole Moderate
- Fosphenytoin + Mebendazole Moderate
Frequently asked questions
Can I take Cimetidine with Mebendazole?
MediHelp rates the interaction as minor. Cimetidine and Mebendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine can increase mebendazole plasma concentrations, which are normally low because of extensive first-pass metabolism. This is mostly relevant with prolonged high-dose therapy for systemic helminth infections such as hydatid disease.
How serious is the interaction between Cimetidine and Mebendazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed for short courses. During long-term high-dose mebendazole, monitor for adverse effects such as hepatotoxicity and neutropenia.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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