Drug interactions
Cimetidine + Modafinil
Severity: Minor
Cimetidine and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Modafinil is a weak enzyme inducer and might slightly lower cimetidine exposure. This has little practical significance.
What this interaction means in plain words
Cimetidine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Modafinil belongs to Central Nervous System.
Why it happens
Modafinil weakly induces hepatic enzymes, possibly increasing cimetidine metabolism.
What to do
No action is needed; reassess acid-suppression response only if symptoms persist.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Modafinil
Frequently asked questions
Can I take Cimetidine with Modafinil?
MediHelp rates the interaction as minor. Cimetidine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Modafinil is a weak enzyme inducer and might slightly lower cimetidine exposure. This has little practical significance.
How serious is the interaction between Cimetidine and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed; reassess acid-suppression response only if symptoms persist.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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