Drug interactions
Cimetidine + Palbociclib
Severity: Minor
Cimetidine and Palbociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a weak CYP3A4 inhibitor and may slightly increase palbociclib exposure. This could increase neutropenia, though the effect is expected to be small. Palbociclib capsule absorption is pH dependent but tablets are not.
What this interaction means in plain words
Cimetidine and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Palbociclib belongs to Oncology.
Why it happens
Weak inhibition of CYP3A4-mediated palbociclib metabolism.
What to do
No dose change is generally needed; monitor neutrophil counts per standard palbociclib monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Palbociclib
Frequently asked questions
Can I take Cimetidine with Palbociclib?
MediHelp rates the interaction as minor. Cimetidine and Palbociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine is a weak CYP3A4 inhibitor and may slightly increase palbociclib exposure. This could increase neutropenia, though the effect is expected to be small. Palbociclib capsule absorption is pH dependent but tablets are not.
How serious is the interaction between Cimetidine and Palbociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor neutrophil counts per standard palbociclib monitoring.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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