Drug interactions
Cimetidine + Ruxolitinib
Severity: Minor
Cimetidine and Ruxolitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine is a weak to moderate CYP3A4 inhibitor and may modestly raise ruxolitinib levels. This could increase myelosuppression such as thrombocytopenia and anemia.
What this interaction means in plain words
Cimetidine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Ruxolitinib belongs to Oncology.
Why it happens
Cimetidine weakly inhibits CYP3A4-mediated metabolism of ruxolitinib.
What to do
No empirical dose change is generally needed; monitor complete blood counts per ruxolitinib labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Ruxolitinib
Frequently asked questions
Can I take Cimetidine with Ruxolitinib?
MediHelp rates the interaction as minor. Cimetidine and Ruxolitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine is a weak to moderate CYP3A4 inhibitor and may modestly raise ruxolitinib levels. This could increase myelosuppression such as thrombocytopenia and anemia.
How serious is the interaction between Cimetidine and Ruxolitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is generally needed; monitor complete blood counts per ruxolitinib labeling.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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