Drug interactions
Cimetidine + Stiripentol
Severity: Minor
Cimetidine and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits P-gp and BCRP, which may modestly increase cimetidine exposure. The clinical significance is likely limited.
What this interaction means in plain words
Cimetidine and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cimetidine belongs to Gastrointestinal Tract; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits P-glycoprotein and BCRP efflux transporters, reducing cimetidine efflux.
What to do
No routine adjustment is needed; reduce the cimetidine dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Cimetidine with Stiripentol?
MediHelp rates the interaction as minor. Cimetidine and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits P-gp and BCRP, which may modestly increase cimetidine exposure. The clinical significance is likely limited.
How serious is the interaction between Cimetidine and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; reduce the cimetidine dose if adverse effects occur.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
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